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Anal infection with human papillomavirus (HPV) is a major risk factor for the cancer. Although an HPV vaccine is in use for the prevention of cervical cancer, it is not being given to prevent anal cancer.
According to both the American Cancer Society and National Cancer Institute, other risk factors for anal cancer include being over 50 years old, having many sexual partners, having receptive anal intercourse, having a weakened immune system, frequent anal redness and soreness, and being a smoker.
Some tumors that develop in the anus are noncancerous. Others start off as benign but develop into cancer over time.
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